Locus Specific Probe for ALK Gene 3' Region    

The ALK 3’ FISH Probe is designed to detect the human ALK gene 3’-region located on chromosome band 2p23.2. ALK is also knownas CD246 or NBLST3.

The ALK 3' FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.

The ALK 3' FISH probe hybridizes to chromosome 2 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct orange fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 2p23.2 region on the chromosome 2. In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 2p23.2. Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 2.

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Analyte Specific Reagent. Analytical and performance characteristics are not established.