The ZFTA Break Apart FISH Probe Kit is designed to detect rearrangements in the human ZFTA gene located on chromosome band 11q13.1. In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other ZFTA aberrations such as deletions or amplifications. Rearrangements and abnormal expression of the ZFTA gene – also known as C11orf95 – have been associated with anaplastic ependymoma, ependymoma, breast invasive ductal carcinoma, clear cell ependymona and other malignancies.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter.