The TRB Break Apart FISH Probe Kit is designed to detect rearrangements in the human TRB gene located on chromosome band 7q34. In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other TRB aberrations such as deletions or amplifications. Rearrangements and abnormal expression of the TRB gene – also known as TCRB or TRB@ – is observed in different types of lymphomas and other malignancies.

The probe set is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it a green fluorescent signal with an appropriate filter.

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