The CTNND2/EGR1 FISH Probe Kit is designed to detect the human CTNND2 gene located on chromosome band 5p15.2, and the EGR1 gene on chromosome band 5q31.2. Abnormal expression of the CTNND2 gene – also known as GT24 or NPRAP  – has been observed in brain and prostate carcinoma and other solid tumor types. Abnormalities in EGR1 – also known as TIS8, AT225, G0S30, NGFI-A, ZNF225, KROX-24 or ZIF-268 – have been observed in myeloid malignancies, fibrosarcoma, lung, brain, breast, skin, prostate liver and various other cancer types. Deletions in the CTNND2 gene region are found in the rare genetic disorder Cri du Chat syndrome.

The probe set is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it a green fluorescent signal with an appropriate filter.

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