This CytoTest FISH probe set is designed to simultaneously determine the copy number of human chromosomes 21, X and Y, and to detect copy number aberrations in these chromosomes, in metaphase and interphase blood and tissue cells. The panel contains three different probes:

CCPX is derived from X-chromosome specific alpha satellite DNA (Xp11.1-q11.1, DXZ1).

CCPY is derived from Y chromosome specific centromeric (Yp11.1-q11.1) alpha satellite DNA (DYZ3).
Note: CCPY probe derived from chromosome Y long arm satellite DNA (DYZ1) can also be provided if preferred.

CCP21 is a probe covering the DSCR8 gene locus located on chromosome band 21q22.2.

The probe is labeled with CytoOrange, CytoGreen and CytoAqua. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter; CytoAqua has an excitation peak at 422 nm and emission peak at 471 nm, giving it an aqua fluorescent signal with an appropriate filter.