The DOCK8/CCP9 FISH Probe Kit is designed to detect the human DOCK8 gene located on chromosome band 9p24.3, along with the number of chromosome 9 copies per cell. Mutations in DOCK8 – also known as MRD2, ZIR8 or HEL-205 – result in the autosomal recessive form of the hyper-IgE syndrome and are associated with colon adenocarcinoma, lung adenocarcinoma, melanoma, breast invasive ductal carcinoma, glioblastoma and other malignancies.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter.