The CIC-DUX4 Dual Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human CIC and DUX4 genes, located on chromosome bands 19q13.2 and 4q35.2, respectively. CIC is also known as KIAA0306 or MRD45. DUX4 is also known as DUX4L. Rearrangements involving portions of these two genes have been observed in Ewing-like sarcomas, oligodendroglioma and other cancers.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter.