The BCOR Break Apart FISH Probe Kit is designed to detect rearrangements in the human BCOR gene located on chromosome band Xp11.4. In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other BCOR aberrations such as deletions or amplifications. Rearrangements and abnormal expression of the BCOR gene – also known as AF4, PBM1 or MLLT2 – have been observed in Round Cell Sarcomas and other malignancies.

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