The CD274/CCP9 FISH Probe Kit is designed to detect the human CD274 gene located on chromosome band 9p24.1, along with the number of chromosome 9 copies per cell. Upregulation of CD274 – also known as PDL1, PDCD1LG1, PDCD1L1, PD-L1, B7H1 or B7-H – has been observed in renal cell carcinoma and in many other cancer types. Altered expression of the gene has also been observed in intracellular infections and in autoimmune conditions.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495nm and emission peak at 518nm, giving it a green fluorescent signal with an appropriate filter.

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