The TP53/MPO FISH Probe Kit is designed to detect rearrangements involving the human TP53 and MPO genes, located on chromosome bands 17p13.1 and 17q22, respectively. Abnormalities in both genes, the TP53 gene – also known as P53, BCC7, LFS1 or TRP53 – and the MPO gene, have been reported in a number of leukemia types and other malignancies.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495nm and emission peak at 518nm, giving it a green fluorescent signal with an appropriate filter.

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