Burkitt's Lymphoma & Other Malignancies Diagnostic Kit     

The CD37/ZNF443 FISH Probe Kit is designed to detect rearrangements involving the human CD37 gene located on chromosome band 19q13.33, along with the region around ZNF443 gene located on chromosome band 19p13.2 measuring the integrity of chromosome 19. Abnormal expression of the CD37 gene – also called GP52-40 or TSPAN26 – is upregulated in Burkitt's lymphoma and other B-cell malignancies, and expressed in a number of solid tumor types as well.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it a green fluorescent signal with an appropriate filter.