The ATRX/CCPX FISH Probe Kit is designed to detect the human ATRX gene located on chromosome band Xq21.1, along with the number of chromosome X copies per cell. Abnormalities in ATRX – also known as ATR2, JMS, MRX52, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP or ZNF-HX – occur in alpha- thalassemia mental retardation syndrome, which a disorder characterized by severe psychomotor retardation, facial dysmorphism, urogenital abnormalities, and alpha-thalassemia. An essential phenotypic trait is hemoglobin H erythrocyte inclusions.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495nm and emission peak at 518nm, giving it an green fluorescent signal with an appropriate filter.

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