The CDK14/CUX1/CCP7 FISH Probe Kit is designed to detect the human CDK14 and CUX1 genes located on chromosome bands 7q21.13 and 7q22.1, respectively, along with the number of chromosome 7 copies per cell. Abnormalities (typically chromosome 7 q-arm deletions) in CDK14 – also known as PFTK1 or PFTAIRE1 – and CUX1 – also called p75, p200, p110, Nbla10317, GOLIM6, FLJ31745, Cux/CDP, Clox, CUX, CUTL1, COY1, CDP1, CDP/Cut, CDP, or CASP – occur in malignant myeloid diseases (ex. CML, AML, etc.) and other malignancies.

The probe is labeled with CytoOrange, CytoGreen and CytoAqua. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it a green fluorescent signal with an appropriate filter; CytoAqua has an excitation peak at 422 nm and emission peak at 471 nm, giving it an aqua fluorescent signal with an appropriate filter.

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