The ZBTB16-RARA Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human ZBTB16 and RARA genes located on chromosome bands 11q23.3 and 17q21.2, respectively. Rearrangements between the two genes, the ZBTB16 gene – also known as PLZF or ZNF145 – and the RARA gene – also called RAR or NR1B1, have been observed in acute promyelocytic leukemia (APL, the M3 subtype of acute myelogenous leukemia) and other malignancies.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter.

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