The DEK-NUP214 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human DEK and NUP214 genes located on chromosome bands 6p22.3 and 9q34.13, respectively. Rearrangements involving portions of these two genes, the DEK gene – also known as D6S231E – and the NUP214 gene – also called CAN, CAIN, or D9S46E, have been observed in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and many other hematological malignancies.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter.

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