The DLEU1/ZBTB16 FISH Probe Kit is designed to detect the human DLEU1 gene, located on chromosome band 13q14.2, and the ZBTB16 gene on chromosome band 11q23.2. Rearrangements and abnormal expression of the DLEU1 gene region – also known as BCMS, DLB1, LEU1, LEU2, XTP6, BCMS1, DLEU2, LINC00021 or NCRNA00021 – have been observed in B-cell chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and other malignancies. Fusions and aberrant expression of the ZBTB16 gene – also known as PLZF or ZNF145 – have been reported in acute promyelocytic leukemia and other neoplasias.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter.