The CDKN2C/CKS1B FISH Probe Kit is designed to detect rearrangements involving the human CDKN2C and CKS1B genes, located on chromosome bands 1p32.3 and 1q21.3, respectively. Abnormalities in CDKN2C – also known as p18, INK4C or p18-INK4C – occur in multiple myeloma and several other malignancies. Abnormal expression of the CKS1B gene – also named CKS1, ckshs1, PNAS-16 or PNAS-18 – has been observed in multiple cancer types, including breast cancer, lymphomas, myeloma, colon, prostate, lung, kidney and numerous other tumor types.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter.