Locus Specific Probe for BCL6 Gene 5' and 3' Region  

The BCL6 5’-3’ FISH Probe is designed to detect the human BCL6 gene located on chromosome band 3q27.3. BCL6 is also known as BCL5, LAZ3, BCL6A, ZNF51 or ZBTB27.

The BCL6 5’-3’ FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.

The BCL6 5’-3’ FISH probe hybridizes to chromosome 3 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct orange fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 3q27.3 region on the chromosome 3. In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 3q27.3. Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 3.

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Analyte Specific Reagent. Analytical and performance characteristics are not established.