The CCP12 probe is designed to detect the copy number of chromosome 12 or to serve as a control to determine the relative copy number of genes located on chromosome 12 and other chromosomes.* The probe is derived from chromosome 12 specific alpha satellite DNA. 

The CCP12 probe is labeled with CytoGreen or CytoAqua. CytoGreen is a fluorophore with an excitation peak at 495 nm and emission peak at 518 nm, giving it a green fluorescent signal with the appropriate filters; CytoAqua is a fluorophore with an excitation peak at 422 nm and emission peak at 471 nm, giving it an aqua fluorescent signal with the appropriate filters. The probe can also be labeled in different colors; please contact us with your specifications.

The CCP12 probe hybridizes to chromosome 12 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct bright fluorescent spots could be observed in the interphase nuclei under a fluorescence microscope. In metaphase cells, bright signals can be observed on the centromere region of chromosome 12 (12p11.1-q11.1). No cross-hybridization to loci on other chromsomes is observed.

* CytoTest shall not be responsible for patent infringement or any other violation that may occur with the use of this product.