The DLEU1/TP53 FISH Probe Kit is designed to detect the human DLEU1 and TP53 genes located on chromosome bands 13q14.2 and 17p13.1, respectively.* Rearrangements and abnormal expression of the DLEU1 gene region – also known as BCMS, DLB1, LEU1, LEU2, XTP6, BCMS1, DLEU2, LINC00021 or NCRNA00021 – and the TP53 gene – also known as P53, BCC7, LFS1 or TRP53 – have been observed in B-cell chronic lymphocytic leukemia (CLL) and other malignancies.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it an green fluorescent signal with an appropriate filter.