The TOP3A/RARA FISH Probe Kit is designed to detect the human TOP3A gene located on chromosome band 17p11.2 and the human RARA gene region located on chromosome band 17q21.2 as a control to determine the number of chromosome 17 or chromosome 17 q-arm copies per cell. Deletions of the TOP3A gene – also known as TOP3, PEOB5, ZGRF7 or MGRISCE2 – region (Smith-Magenis Region) are found in   Smith-Magenis Syndrome and other malignancies.

The probe set is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it a green fluorescent signal with an appropriate filter.

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