The TP53/ATM/D13S319/LAMP1/CCP12 FISH Probe Kit is designed to simultaneously detect rearrangements involving the human TP53, ATM, D13S319 and LAMP1 genes, located on chromosome bands 17q13.1, 11q22.3, 13q14.2, and 13q34, respectively. Gains and losses of these loci have been observed in B-cell chronic lymphocytic leukemia (CLL) and other neoplasms.

The probe set is labeled with CytoOrange, CytoGreen and CytoAqua. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it a green fluorescent signal with an appropriate filter; CytoAqua has an excitation peak at 422 nm and emission peak at 471 nm, giving it an aqua fluorescent signal with an appropriate filter.