Lymphoma & Other Malignancies Diagnostic Kit     

The TP53/CD37 FISH Probe Kit is designed to detect rearrangements involving the human TP53 and CD37 genes located on chromosome bands 17p13.1 and 19q13.33, respectively.* Abnormal expression of the TP53 gene – also known as P53, BCC7, LFS1 or TRP53 – has been observed in a large number of tumor types and some other conditions. The CD37 gene – also called GP52-40 or TSPAN26 – is upregulated in Burkitt's lymphoma and other B-cell malignancies, and expressed in a number of solid tumor types as well.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551 nm and emission peak at 575 nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495 nm and emission peak at 518 nm, giving it a green fluorescent signal with an appropriate filter.