Locus Specific Probe for ATRX Gene    

The ATRX FISH Probe is designed to detect the human ATRX gene located on chromosome band Xq21.1. ATRX is also known as ATR2, JMS, MRX52, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP or ZNF-HX.

The ATRX FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.

The ATRX FISH probe hybridizes to chromosome X in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, one or two distinct fluorescent spots are observed in the interphase nuclei, each spot corresponding to the Xq21.1 region on the chromosome X. In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region Xq21.1. Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome X.

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Analyte Specific Reagent. Analytical and performance characteristics are not established.