Locus Specific Probe for ATM Gene            

The ATM FISH Probe is designed to detect the human ATM gene located on chromosome band 11q22.3. ATM is also known as AT1, ATA, ATC, ATD, ATE, ATDC, TEL1 or TELO1.

The ATM FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.

The ATM FISH probe hybridizes to chromosome 11 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct orange fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 11q22.3 region on the chromosome 11.  In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 11q22.3.  Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 11.

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Analyte Specific Reagent. Analytical and performance characteristics are not established.