Locus Specific Probe for ARSA Gene       

The ARSA FISH Probe is designed to detect the human ARSA gene located on chromosome band 22q13.33. ARSA is also known as MLD.

The ARSA FISH probe is labeled with CytoGreen. CytoGreen is a fluorophore with an excitation peak at 495nm and emission peak at 518nm, giving it an green fluorescent signal with the appropriate filters.

The ARSA FISH probe hybridizes to chromosome 22 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 22q13.33 region on the chromosome 22.  In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 22q13.33.  Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 22.

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Analyte Specific Reagent. Analytical and performance characteristics are not established.