The ATM/GLI1 FISH Probe Kit is designed to detect rearrangements involving the human ATM and GLI1 genes located on chromosome bands 11q22.3 and 12q13.3, respectively.* Abnormalities in ATM – also known as AT1, ATA, ATC, ATD, ATE, ATDC, TEL1 or TELO1 – occur in ataxia telangiectasia, and have also been observed in chronic lymphocytic leukemia (CLL) and other malignancies. The GLI1 gene – also called GLI – is an oncogene that is expressed and sometimes amplified in several human cancers.

The probe is labeled with CytoOrange and CytoGreen. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with an appropriate filter; CytoGreen has an excitation peak at 495nm and emission peak at 518nm, giving it an green fluorescent signal with an appropriate filter.

* CytoTest shall not be responsible for patent infringement or any other violation that may occur with the use of this product.